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KMID : 0043320090320040583
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Archives of Pharmacal Research
2009 Volume.32 No. 4 p.583 ~ p.591
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Resveratrol Inhibits Porphyromonas gingivalis Lipopolysaccharideinduced Endothelial Adhesion Molecule Expression by Suppressing NF-κB Activation
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Bae Moon-Kyoung
Kim Kyu-Won
Yun Il
Jang Hye-Ock
Koo Tae-Hyeon
Jin Seong-Deok
Kim Woo-Sik
Bae Soo-Kyung
Park Hyun-Joo
Kim Su-Ryun
Jeong Seong-Kyoon
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Abstract
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P. gingivalis is a major pathogen that is involved in the onset and progression of periodontal disease. This study investigated the effect of resveratrol, a naturally occurring polyphenol, on P. gingivalis LPS-accelerated vascular inflammation, a key step in the progression of periodontitis. Resveratrol significantly inhibited the P. gingivalis LPS-induced adhesion of leukocytes to endothelial cells and to the aortic endothelium by down-regulating the cell adhesion molecules, ICAM-1 and VCAM-1. Moreover, the inhibition of the P. gingivalis LPS-induced cell adhesion molecules by resveratrol was mainly mediated by nuclear factor-κB (NF-κB). Resveratrol suppressed P. gingivalis LPS-stimulated IκBα phosphorylation and nuclear translocation of the p65 subunit of NF-κB in HMECs. Overall, these findings suggest that resveratrol significantly attenuates the P. gingivalis LPS-induced monocyte adhesion to the endothelium by suppressing the expression of the NF-κB-dependent cell adhesion molecules, suggesting its therapeutic role in periodontal pathogen-induced vascular inflammation.
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KEYWORD
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Cell adhesion molecules, Nuclear factor-κB, Porphyromonas gingivalis lipopolysaccharide, Resveratrol, Vascular endothelial cells
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